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Description
Flunixin Meglumine Granules Instructions
Veterinary
【Drug Name】
Generic Name: Flunixin Meglumine Granules
Product Name: Shenganshu
English Name: Flunixin Meglumine Granules
Pinyin: Funixin Pujia’an Keli
【Main Ingredient】Flunixin Meglumine.
【Properties】This product is a whitish or light yellow granule.
【Pharmacological Action】
Pharmacodynamics: Flunixin Meglumine is a potent cyclooxygenase inhibitor with analgesic, antipyretic, anti-inflammatory, and anti-rheumatic effects. The analgesic effect is achieved by inhibiting the synthesis of peripheral prostaglandins or their pain-sensitizing substances, thereby blocking the transmission of pain impulses. The anti-inflammatory effect in peripheral tissues may be due to the inhibition of cyclooxygenase, reduction of prostaglandin precursors, and suppression of other mediators causing local inflammatory responses. Flunixin Meglumine does not affect gastrointestinal motility in horses but may improve hemodynamics in animals with septic shock.
Pharmacokinetics: After a single intramuscular injection in pigs (2.2 mg/kg body weight), the plasma elimination half-life is 3 to 4 hours, the peak concentration is 2.94 μg/mL, the time to reach peak concentration is 0.4 hours, and the drug can still be detected in the blood 18 hours after administration. The apparent volume of distribution is 2.0 L/kg, and the bioavailability after a single neck injection is 87%.
【Drug Interactions】
(1) Concurrent use with other non-steroidal anti-inflammatory drugs may exacerbate gastrointestinal toxicity, such as ulcers and bleeding.
(2) Due to the high plasma protein binding rate, when used in combination with other drugs, Flunixin Meglumine may displace other drugs bound to plasma proteins or itself be displaced by other drugs, leading to enhanced effects of the displaced drugs, or even toxicity.
【Effects and Applications】Antipyretic and analgesic anti-inflammatory drug. Used for febrile and inflammatory diseases, muscle pain, and soft tissue pain in livestock and small animals.
【Dosage and Administration】 Based on this product. For oral administration: single dose, 40mg per 1kg body weight for dogs and cats, once or twice a day, not exceeding 5 days of continuous use.
【Adverse Reactions】 Long-term high-dose use of this product may lead to gastric ulcers and kidney function damage in animals.
【Precautions】
(1) Use with caution in animals with gastrointestinal ulcers.
(2) Do not use concurrently with other non-steroidal anti-inflammatory drugs.
【Withdrawal Period】 No need to establish.
【Specifications】 Calculated as C14H11F3N2O2 5%.
【Storage】 Store in a light-proof, sealed container.
Key words:
Sheng An Shu
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